Journal
G3-GENES GENOMES GENETICS
Volume 8, Issue 1, Pages 123-130Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/g3.117.300073
Keywords
abnormal chromosome 10; autosomal drive; neocentromere; segregation distortion; selfish genetic element
Categories
Funding
- National Science Foundation [1412063]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1412063] Funding Source: National Science Foundation
Ask authors/readers for more resources
Autosomal drivers violate Mendel's law of segregation in that they are overrepresented in gametes of heterozygous parents. For drivers to be polymorphic within populations rather than fixing, their transmission advantage must be offset by deleterious effects on other fitness components. In this paper, we develop an analytical model for the evolution of autosomal drivers that is motivated by the neocentromere drive system found in maize. In particular, we model both the transmission advantage and deleterious fitness effects on seed viability, pollen viability, seed to adult survival mediated by maternal genotype, and seed to adult survival mediated by offspring genotype. We derive general, biologically intuitive conditions for the four most likely evolutionary outcomes and discuss the expected evolution of autosomal drivers given these conditions. Finally, we determine the expected equilibrium allele frequencies predicted by the model given recent estimates of fitness components for all relevant genotypes and show that the predicted equilibrium is within the range observed in maize land races for levels of drive at the low end of what has been observed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available