Journal
BIOMATERIALS
Volume 127, Issue -, Pages 75-88Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2017.02.029
Keywords
Biomineralization; Carbonate; Substitution; Calcium phosphate; Bone
Funding
- National Institute of Health (NIH) [R01 EB016422, R01 AR057836]
- National Space Biomedical Research Institute [NSBRI-RFA-13-01]
- Department of Mechanical Engineering, University Arkansas
- National Science Foundation [0963249, 0959124, 0918970]
- Arkansas Science and Technology Authority
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1548571] Funding Source: National Science Foundation
Ask authors/readers for more resources
The nanometer-sized plate-like morphology of bone mineral is necessary for proper bone mechanics and physiology. However, mechanisms regulating the morphology of these mineral nanocrystals remain unclear. The dominant hypothesis attributes the size and shape regulation to organic-mineral interactions. Here, we present data supporting the hypothesis that physicochemical effects of carbonate integration within the apatite lattice control the morphology, size, and mechanics of bioapatite mineral crystals. Carbonated apatites synthesized in the absence of organic molecules presented plate-like morphologies and nanoscale crystallite dimensions. Experimentally-determined crystallite size, lattice spacing, solubility and atomic order were modified by carbonate concentration. Molecular dynamics (MD) simulations and density functional theory (DFT) calculations predicted changes in surface energy and elastic moduli with carbonate concentration. Combining these results with a scaling law predicted the experimentally observed scaling of size and energetics with carbonate concentration. The experiments and models describe a clear mechanism by which crystal dimensions are controlled by carbonate substitution. Furthermore, the results demonstrate that carbonate substitution is sufficient to drive the formation of bone-like crystallites. This new understanding points to pathways for biomimetic synthesis of novel, nanostructured biomaterials. (C) 2017 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available