Journal
FRONTIERS IN AGING NEUROSCIENCE
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2017.00155
Keywords
mobility; gait; balance; aging; cognition; MRI; gray matter
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Funding
- NIHR Oxford Biomedical Research Centre based at the Oxford University Hospitals NHS Trust
- University of Oxford
- Elizabeth Casson Trust Chair
- British Research Council
- UK Medical Research Council
- NordForsk
- British Heart Foundation
- US National Institute of Health [R01AG013196, R01AG034454, R01HL036310]
- MRC [MR/L023784/1, MR/M024962/1, MC_EX_MR/N50192X/1, MR/K013351/1, G1001354] Funding Source: UKRI
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Mobility limitations lead to a cascade of adverse events in old age, yet the neural and cognitive correlates of mobility performance in older adults remain poorly understood. In a sample of 387 adults (mean age 69.0 +/- 5.1 years), we tested the relationship between mobility measures, cognitive assessments, and MRI markers of brain structure. Mobility was assessed in 2007-2009, using gait, balance and chair-stands tests. In 2012-2015, cognitive testing assessed executive function, memory and processing-speed; gray matter volumes (GMV) were examined using voxel-based morphometry, and white matter microstructure was assessed using tract-based spatial statistics of fractional anisotropy, axial diffusivity (AD), and radial diffusivity (RD). All mobility measures were positively associated with processing-speed. Faster walking speed was also correlated with higher executive function, while memory was not associated with any mobility measure. Increased GMV within the cerebellum, basal ganglia, post-central gyrus, and superior parietal lobe was associated with better mobility. In addition, better performance on the chair-stands test was correlated with decreased RD and AD. Overall, our results indicate that, even in non-clinical populations, mobility measures can be sensitive to sub-clinical variance in cognition and brain structures.
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