Journal
ANALYTICA CHIMICA ACTA
Volume 965, Issue -, Pages 103-110Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2017.02.006
Keywords
Pyrido[1,2-a]benzimidazole; Bioimaging; FRET; Fluorescent probe; Cu2+
Categories
Funding
- National Natural Science Foundation of China [21602153]
- Taishan Medical University [2013GCC02]
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A novel fluorophore pyrido[1,2-a] benzimidazole was synthesized and used as a donor to construct FRET system. The probe shows a large Stokes shifts (190 nm), high selectivity, fast response (within 2 min), and high sensitivity toward Cu2+ (detection limit 42 nM). A significant colour change from colourless to pink could be observed, enabling naked-eye detection of Cu2+. Furthermore, it could be used for imaging Cu2+ in living cells which demonstrated its value of practical applications in biological systems. (C) 2017 Elsevier B. V. All rights reserved.
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