4.7 Article

DNA-spheres decorated with magnetic nanocomposites based on terminal transfer reactions for versatile target detection and cellular targeted drug delivery

Journal

CHEMICAL COMMUNICATIONS
Volume 53, Issue 35, Pages 4826-4829

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc00310b

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Funding

  1. National Natural Science Foundation of China [21575056, 21535002]
  2. Natural Science Foundation of Shandong Province of China [ZR2016JL010]
  3. Program for New Century Excellent Talents in University of Ministry of Education of China [NCET-13-0845]

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We present an elegant approach to make a magnetic nanoparticle (MNP) conjugated DNA-sphere (MNP/DNA-SP) which is integrated with disulfide (MNP/DS-SP) or an aptamer (MNP/sgc8-SP) for GSH detection, selective cancer cell recognition, effective drug delivery, and bioimaging.

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