Journal
ACS NANO
Volume 11, Issue 5, Pages 4907-4915Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.7b01519
Keywords
solid-state nanopore; in situ; meniscus contact; pipette; dielectric breakdown; capacitance; array
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In this article, we introduce a flexible technique for high-throughput solid-state nanopore analysis of single biomolecules. By confining the electrolyte to a micron-scale liquid meniscus at the tip of a glass micropipette, we enable automation and reuse of a single solid-state membrane chip for measurements with hundreds of distinct nanopores per day. In addition to overcoming important experimental bottlenecks, the microscale liquid contact dramatically reduces device capacitance, which is a key limiting factor to the speed and fidelity of solid-state nanopore sensor recordings.
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