Journal
NATURE REVIEWS IMMUNOLOGY
Volume 17, Issue 5, Pages 333-340Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri.2016.153
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Funding
- Japan Society for the Promotion of Science
- Core Research for Evolutional Science and Technology (CREST) grants from Japan Science and Technology Agency
- Grants-in-Aid for Scientific Research [26110006, 17H04068, 26293089, 15H05785] Funding Source: KAKEN
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More than 50 years ago, cells were observed to die during insect development via a process that was named 'programmed cell death'. Later, a similar cell death process was found to occur in humans, and the process was renamed 'apoptosis'. In the 1990s, a number of apoptosis-regulating molecules were identified, and apoptosis was found to have essential roles in the immune system. In this Timeline article, we highlight the key events that have demonstrated the importance of programmed cell death processes, including apoptosis and programmed necrosis, in the immune system.
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