Journal
CELL CALCIUM
Volume 63, Issue -, Pages 20-23Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2016.12.003
Keywords
-
Categories
Funding
- MRC [MR/L01047X/1] Funding Source: UKRI
- Medical Research Council [MR/L01047X/1] Funding Source: researchfish
- Medical Research Council [MR/L01047X/1] Funding Source: Medline
Ask authors/readers for more resources
CRAC channels are a major route for Ca2+ influx in eukaryotic cells. The channels show prominent Ca2+-dependent inactivation through two spatially and temporally distinct mechanisms: fast inactivation, which develops over milliseconds and is triggered by Ca2+ near the mouth of the channel and slow inactivation, which arises over tens of seconds and requires a rise in global cytosolic Ca2+. Slow inactivation is controlled physiologically by Ca2+ uptake into mitochondria through the MCU. Site-directed mutagenesis studies on STIM1 and Orai1 have led to new molecular insight into how fast inactivation occurs. This review describes properties and molecular mechanisms that contribute to these important Ca2+-dependent inhibitory pathways. (C) 2016 Published by Elsevier Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available