Journal
NATURE REVIEWS IMMUNOLOGY
Volume 17, Issue 5, Pages 295-305Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri.2017.12
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Funding
- Ministry of Education, Culture, Sports, Science and Technology-Japan Society for the Promotion of Science (MEXT-JSPS) [24111004, 16H02630, 15K19130]
- UK Medical Research Council (MRC) Programme grant
- Cancer Research UK (CRUK) Cancer Immunology grant
- Royal Society
- Daiwa Anglo-Japanese Foundation
- MEXT-JSPS (the MEXT Joint Usage Research Center Program)
- MEXT-JSPS (the JSPS Open Partnership Joint Project)
- Grants-in-Aid for Scientific Research [24111004, 24111001, 15K19130, 16H02630, 17K08884] Funding Source: KAKEN
- Cancer Research UK [20753] Funding Source: researchfish
- Medical Research Council [MR/N000919/1] Funding Source: researchfish
- MRC [MR/N000919/1] Funding Source: UKRI
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In the thymus, diverse populations of thymic epithelial cells (TECs), including cortical and medullary TECs and their subpopulations, have distinct roles in coordinating the development and repertoire selection of functionally competent and self-tolerant T cells. Here, we review the expanding diversity in TEC subpopulations in relation to their functions in T cell development and selection as well as their origins and development.
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