Journal
FUTURE SCIENCE OA
Volume 3, Issue 2, Pages -Publisher
FUTURE SCI LTD
DOI: 10.4155/fsoa-2016-0091
Keywords
microfluidic devices; organ-on-a-chip; stem cell; stem cell culture; stem cell differentiation
Categories
Funding
- NIH/NIAID [R21AI107415]
- NIH/NIGMS [SC2GM105584]
- US NSF-PREM program [DMR 1205302]
- IDR Program at the UTEP
- NIH RCMI Pilot Grant
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1205302] Funding Source: National Science Foundation
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Microfluidic lab-on-a-chip provides a new platform with unique advantages to mimic complex physiological microenvironments in vivo and has been increasingly exploited to stem cell research. In this review, we highlight recent advances of microfluidic devices for stem-cell culture and differentiation toward the development of organon-a-chip, especially with an emphasis on vital innovations within the last 2 years. Various aspects for improving on-chip stem cell culture and differentiation, particularly toward organ-on-a-chip, are discussed, along with microenvironment control, surface modification, extracellular scaffolds, high throughput and stimuli. The combination of microfluidic technologies and stem cells hold great potential toward versatile systems of 'organ-on-a-chip' as desired. Stem cells, capable of self-renewing and differentiating into cells of various tissue types, are drawing more and more attention for their enormous potential in many clinically associated applications that include drug screening, disease modeling and regenerative medicine. Conventional cell culture methods, however, have proven to be difficult to mimic in vivo like microenvironments and to provide a number of well-controlled stimuli that are critical for stem cell culture and differentiation. In contrast, microfluidic devices offer new capacities and unique advantages to mimic complex physiological microenvironments in vivo, and has been increasingly applied to stem cell research.
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