Journal
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
Volume 7, Issue 10, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a024331
Keywords
-
Categories
Funding
- Tau Consortium
- JPB Foundation
- Cure Alzheimer's Fund
Ask authors/readers for more resources
The astonishing findings that active and passive immunization against amyloid-beta (A beta) in mouse models of Alzheimer's disease (AD) dramatically decreased amyloid burden led to a rapid initiation of human clinical trials with much enthusiasm. However, methodological issues and adverse effects relating to these clinical trials arose, challenging the effectiveness and safety of these reagents. Efforts are now underway to develop safer immunotherapeutic approaches toward Ab and the treatment of individuals at risk for AD before or in the earliest stages of cognitive decline with newhopes. Furthermore, several studies have shown tau as a potential immunotherapeutic target for the treatment of tauopathy-related diseases including frontotemporal lobar dementia (FTLD). Both active and passive immunization targeting tau in mouse models of tauopathy effectively decreased tau pathologywhile improving cognitive performance. These preclinical studies have highlighted tau as an alternative target with much anticipation of clinical trials to be undertaken.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available