Journal
ACS NANO
Volume 11, Issue 5, Pages 4651-4659Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.7b00343
Keywords
antibacterial depot; molybdenum disulfide; silver nanoparticles; wound infection; negligible biotoxicity
Categories
Funding
- National Natural Science Foundation of China [21210002, 21431007, 21533008, 21403209, 21601175]
- Jilin Province Science and Technology Development Plan Project [20140101039JC]
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Silver nanoparticles (AgNPs) have been used as a broad-spectrum antimicrobial agent, whose toxicity originates from the localized release of Ag+ ions. However, the residual AgNPs core could generate potential risk to humans and waste of noble metals. Herein, we infused the cysteine-modified molybdenum disulfide with minimum Ag+ ions and coated with a layer of cationic polyelectrolyte to construct an efficient and benign antimicrobial depot. The system exhibited much enhanced broad-spectrum antibacterial activity compared with an equivalent amount of silver nitrate, owing to its increasing accessibility of released Ag+ to the cell walls of microorganisms. More importantly, the antibacterial system could be successfully applied to treat wound infection, while retaining high antibacterial activities, exhibiting negligible biotoxicity and avoiding the waste of Ag.
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