Journal
CHEMPLUSCHEM
Volume 82, Issue 3, Pages 407-415Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cplu.201600617
Keywords
biocatalysis; chemoselectivity; enzyme catalysis; fragrances; natural products
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Funding
- Universite Nice Sophia Antipolis
- CNRS
- SATT sud-est
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A lipase-catalyzed acylation reaction of crude Haitian vetiver essential oil was studied as an alternative to chemical processes for the manufacture of an industrially relevant fragrance ingredient. A competitive process that involved a recyclable immobilized lipase at 10% w/w was developed and used up to the kilogram scale and quantitatively delivered the target product with good productivity (up to 90 gL(-1) h(-1)). With the support of comprehensive two-dimensional gas chromatography/mass spectrometry (GCxGC-MS), it was found that the enzymatic reaction exhibited a high chemoselectivity in favor of primary sesquiterpene alcohols. This finding and its consequence on the olfactory properties were correlated with sensory analysis.
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