Journal
CELL REPORTS
Volume 21, Issue 4, Pages 1048-1062Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2017.09.095
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Funding
- National Science Foundation
- NIH [R01 EY023648, 1U54HD090255, P30 EY012196, T32 HL007901, UL1 TR001102]
- Whitehall Foundation [2011-05-15]
- Karl Kirchgessner Foundation
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Intrinsically photosensitive retinal ganglion cells of the M1 type encode environmental irradiance for functions that include circadian and pupillary regulation. Their distinct role, morphology, and molecular markers indicate that they are stereotyped circuit elements, but their physiological uniformity has not been investigated in a systematic fashion. We have profiled the biophysical parameters of mouse M1s and found that extreme variation is their hallmark. Most parameters span 1-3 log units, and the full range is evident in M1s that innervate brain regions serving divergent functions. Biophysical profiles differ among cells possessing similar morphology and between neighboring M1s recorded simultaneously. Variation in each parameter is largely independent of that in others, allowing for flexible individualization. Accordingly, a common stimulus drives heterogeneous spike outputs across cells. By contrast, a population of directionally selective retinal ganglion cells appeared physiologically uniform under similar conditions. Thus, M1s lack biophysical constancy and send diverse signals downstream.
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