Journal
CELL REPORTS
Volume 21, Issue 13, Pages 3914-3926Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2017.12.027
Keywords
-
Categories
Funding
- Helmholtz Association [VH-NG-933]
- German Research Foundation (DFG) [SPP1656, STR1343/1-1, STR1343/1-2]
Ask authors/readers for more resources
Contradicting observations have been made regarding the relative contributions of immune sensors to shaping the microbiome, yet the reasons for these discrepancies are not fully understood. Here, we investigated the contribution of environmental factors in shaping the microbiome in mice deficient in adaptive immunity (Rag2(-/-)) and Nlrp6, an immune sensor proposed to be involved in regulation of microbiota composition. In conventionally housed Nlrp6(-/-) mice, familial transmission has a significant effect on microbiota composition, complicating the analysis of genotype-dependent effects. Notably, after rederivation into standardized specific pathogen-free (SPF) conditions devoid of pathobionts, microbiota composition was indistinguishable between WT, Rag2(-/-), and Nlrp6(-/-) mice. However, upon reintroduction of a pathobiont-containing community host, genotype-dependent differences reappear, specifically affecting the relative abundance of pathobionts such as Helicobacter spp. Our results show that the impact of Nlrp6 and also of adaptive immunity on microbiota composition depends on community structure and primarily influences pathobionts but not commensals.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available