Journal
CELL REPORTS
Volume 18, Issue 10, Pages 2343-2358Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2017.02.028
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Funding
- Terry Fox Research Institute [2012-46]
- Ovarian Cancer Canada's Teal Heart Scholarship Fund
- Fond de Recherche en Sante du Quebec (FRSQ) [33657]
- OICR
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The degree of genetic aberrations characteristic of high-grade serous ovarian cancer (HGSC) makes identification of the molecular features that drive tumor progression difficult. Here, we perform genomewide RNAi screens and comprehensive expression analysis of cell-surface markers in a panel of HGSC cell lines to identify genes that are critical to their survival. We report that the tetraspanin CD151 contributes to survival of a subset of HGSC cell lines associated with a ZEB transcriptional program and supports the growth of HGSC tumors. Moreover, we show that high CD151 expression is prognostic of poor clinical outcome. This study reveals cell-surface vulnerabilities associated with HGSC, provides a framework for identifying therapeutic targets, and reports a role for CD151 in HGSC.
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