Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 23, Issue 18, Pages 4292-4297Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201604722
Keywords
attractive nanoemulsions; block copolymers; drop-percolated emulsion; drug delivery; lecithin
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Funding
- National Research Foundation of Korea (NRF) - Korea government (MSIP) [2008-0061891, 2016R1A2B2016148]
- National Science Foundation [DMR-1609841]
- National Research Foundation of Korea [2016R1A2B2016148] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1609841] Funding Source: National Science Foundation
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This study introduces an extremely stable attractive nanoscale emulsion fluid, in which the amphiphilic block copolymer, poly(ethylene oxide)-block-poly(e-caprolactone) (PEO-b-PCL), is tightly packed with lecithin, thereby forming a mechanically robust thin-film at the oil-water interface. The molecular association of PEO-b-PCL with lecithin is critical for formation of a tighter and denser molecular assembly at the interface, which is systematically confirmed by T-2 relaxation and DSC analyses. Moreover, suspension rheology studies also reflect the interdroplet attractions over a wide volume fraction range of the dispersed oil phase; this results in a percolated network of stable drops that exhibit no signs of coalescence or phase separation. This unique rheological behavior is attributed to the dipolar interaction between the phosphorylcholine groups of lecithin and the methoxy end groups of PEO-b-PCL. Finally, the nanoemulsion system significantly enhances transdermal delivery efficiency due to its favorable attraction to the skin, as well as high diffusivity of the nanoscale emulsion drops.
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