Journal
ACS OMEGA
Volume 2, Issue 3, Pages 800-805Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.6b00514
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Funding
- National Institutes of Health [EB013663]
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We report, for the first time, a multimodal, oxidation-responsive contrast agent for magnetic resonance imaging and photoacoustic imaging that uses the differences in the properties between Eu in the +2 and +3 oxidation states. The enhancement of contrast in T-1-weighted magnetic resonance and photoacoustic imaging was observed in the +2 but not in the +3 oxidation state, and the complex is a known chemical exchange saturation transfer agent for magnetic resonance imaging in the +3 oxidation state.
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