Journal
CELL REPORTS
Volume 21, Issue 10, Pages 2760-2771Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2017.11.035
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Funding
- National Institute of Dental and Craniofacial Research (NIDCR)
- National Center for Complementary and Integrative Health (NCCIH)
- Office of the Director NIH
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Piezo2 is a mechanically activated ion channel required for touch discrimination, vibration detection, and proprioception. Here, we discovered that Piezo2 is extensively spliced, producing different Piezo2 isoforms with distinct properties. Sensory neurons from both mice and humans express a large repertoire of Piezo2 variants, whereas non-neuronal tissues express predominantly a single isoform. Notably, even within sensory ganglia, we demonstrate the splicing of Piezo2 to be cell type specific. Biophysical characterization revealed substantial differences in ion permeability, sensitivity to calcium modulation, and inactivation kinetics among Piezo2 splice variants. Together, our results describe, at the molecular level, a potential mechanism by which transduction is tuned, permitting the detection of a variety of mechanosensory stimuli.
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