Journal
CELL REPORTS
Volume 19, Issue 8, Pages 1572-1585Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2017.04.078
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Funding
- Cancer Research Institute
- American Heart Association Postdoctoral Fellowship [13POST16190005]
- NIH T32 Research in Hematology Grant [HL07899]
- University of Wisconsin Carbone Cancer Center support grant [P30 CA014520]
- NIH [R01EB010039, R35 GM1 18027 01]
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Motile cells navigate through complex tissue environments that include both attractive and repulsive cues. In response to tissue wounding, neutrophils, primary cells of the innate immune response, exhibit bidirectional migration that is orchestrated by chemokines and their receptors. Although progress has been made in identifying signals that mediate the recruitment phase, the mechanisms that regulate neutrophil reverse migration remain largely unknown. Here, we visualize bidirectional neutrophil migration to sterile wounds in zebrafish larvae and identify specific roles for the chemokine receptors Cxcr1 and Cxcr2 in neutrophil recruitment to sterile injury and infection. Notably, we also identify Cxcl8a/Cxcr2 as a specific ligand-receptor pair that orchestrates neutrophil chemokinesis in interstitial tissues during neutrophil reverse migration and resolution of inflammation. Taken together, our findings identify distinct receptors that mediate bidirectional leukocyte motility during interstitial migration depending on the context and type of tissue damage in vivo.
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