Journal
CELL AND BIOSCIENCE
Volume 7, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/s13578-017-0136-8
Keywords
DNA double-strand breaks (DSBs); Microhomology-mediated end joining (MMEJ); End resection; RPA; Pol theta
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Funding
- 973 projects [2015CB910601/2, 2013CB911002]
- National Natural Science Foundation of China (NSFC) [31370841, 31530016, 31461143012]
- Importation and Development of High-Caliber Talents Project of Beijing Municipal Institutions [CITTCD201504069]
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DNA double-strand breaks (DSBs) are the most deleterious type of DNA damage in cells arising from endogenous and exogenous attacks on the genomic DNA. Timely and properly repair of DSBs is important for genomic integrity and survival. MMEJ is an error-prone repair mechanism for DSBs, which relies on exposed microhomologous sequence flanking broken junction to fix DSBs in a Ku- and ligase IV-independent manner. Recently, significant progress has been made in MMEJ mechanism study. In this review, we will summarize its biochemical activities of several newly identified MMEJ factors and their biological significance.
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