Journal
MEDICAL GAS RESEARCH
Volume 7, Issue 1, Pages 48-55Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/2045-9912.202910
Keywords
isoflurane; volatile anesthetics; stroke; neuroprotection; ischemia; experimental studies; pre-conditioning; post-conditioning; mechanism
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Funding
- Suzhou Key Medical Center of China [Szzx201501]
- National Natural Science Foundation of China [81571115, 81422013, 81471196]
- Scientific Department of Jiangsu Province of China [BL2014045]
- Projects of Invigorating Health Care through Science, Technology and Education, Suzhou Government [SZS201413, SYS201608, LCZX201601]
- Jiangsu Province [16KJB320008]
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Isoflurane, a volatile and inhalational anesthetic, has been extensively used in perioperative period for several decades. A large amount of experimental studies have indicated that isoflurane exhibits neuroprotective properties when it is administrated before or after (pre-conditioning and post-conditioning) neurodegenerative diseases (e.g., hypoxic ischemia, stroke and trauma). Multiple mechanisms are involved in isoflurane induced neuroprotection, including activation of glycine and -aminobutyric acid receptors, antagonism of ionic channels and alteration of the function and activity of other cellular proteins. Although neuroprotection provided by isoflurane is observed in many animal studies, convincing evidence is lacking in human trials. Therefore, there is still a long way to go before translating its neuroprotective properties into clinical practice.
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