Journal
AUTOIMMUNITY REVIEWS
Volume 16, Issue 5, Pages 456-460Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2017.03.009
Keywords
Theory of focal infection; S. mutans antigen I/II; Cardiovascular autoantigens; Peptide sharing; Crossreactivity; Autoimmunity
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Infectious pathogens from the oral cavity cause oral diseases such as caries, gingivitis, periodontitis, endodontic infections, and alveolar osteitis, and often are also concomitant to systemic diseases, including cardiovascular disorders, stroke, preterm birth, diabetes, and pneumonia, among others. The relationship(s) between oral infections and systemic diseases are still unclear. Using the bacterial cell surface antigen I/II from S. mutans and cardiovascular diseases as a model, this study analyzes peptide commonalities that might underlie autoimmune crossreactions between the bacterial antigen and human proteins associated with cardiovascular disorders. The study outlines a vast peptide sharing that calls attention on autoimmune crossreactivity as a possible mechanism by which S. mutans infection might contribute to induce cardiovascular diseases, and, more in general, offers a new approach to investigate the still elusive molecular links between focal oral infections and human systemic diseases. (C) 2017 Elsevier B.V. All rights reserved.
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