Journal
CHEMBIOCHEM
Volume 18, Issue 9, Pages 829-836Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201600567
Keywords
chemical biology; combinatorial chemistry; drug discovery; encoded libraries; high-throughput screening
Funding
- University of Utah
- Huntsman Cancer Institute
- Utah Science and Technology Research (USTAR) Initiative
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DNA-encoded chemical libraries (DECLs) are pools of DNA-tagged small molecules that enable facile screening and identification of bio-macromolecule binders. The successful development of DECLs has led to their increasingly important role in drug development, and screening hits have entered clinical trials. In this review, we summarize the development and currently active research areas of DECLs with a focus on contributions from groups at academic institutes. We further look at opportunities and future directions of DECL research in medicinal chemistry and chemical biology based on the symbiotic relationship between academia and industry. Challenges associated with the application of DECLs in academic drug discovery are further discussed.
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