Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 36, Pages 4919-4921Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc02183f
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Funding
- EPSRC [EP/K004980/1]
- Simons Foundation [318881]
- EPSRC [EP/K004980/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/K004980/1] Funding Source: researchfish
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RNA is essential to all life on Earth and is the leading candidate for the first biopolymer of life. Aminooxazolines have recently emerged as key prebiotic ribonucleotide precursors, and here we develop a novel strategy for aminooxazoline-5'-phosphate synthesis in water from prebiotic feedstocks. Oxidation of acrolein delivers glycidaldehyde (90%), which directs a regioselective phosphorylation in water and specifically affords 5'-phosphorylated nucleotide precursors in upto 36% yield. We also demonstrated a generational link between proteinogenic amino acids (Met, Glu, Gln) and nucleotide synthesis.
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