Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 37, Pages 5151-5154Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc01069a
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Funding
- National Nature Science Foundation of China [21232004, 21402117, 21620102003]
- Science and Technology Commission of Shanghai Municipality [14XD1402300, 15Z111220016]
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Allylic alcohols and allylic amines were directly utilized in a Pd-catalyzed hydrogen-bond-activated allylic amination under mild reaction conditions in the absence of any additives. The cooperative action of a Pd-catalyst and a hydrogen-bonding solvent is most likely responsible for its high reactivity. The catalytic system is compatible with a variety of functional groups and can be used to prepare a wide range of linear allylic amines in good to excellent yields. Furthermore, this methodology can be easily applied to the one-step synthesis of two drugs, cinnarizine and naftifine, on a gram scale.
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