☆ 4.5 Article

Evaluation of anti-diabetic effect and gall bladder function with 2-thio-5-thiomethyl substituted imidazoles as TGR5 receptor agonists

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)

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Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 27, Issue 8, Pages 1760-1764

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2017.02.069

Keywords

TGR5; lmidazole; OGTT; Gall bladder

Categories

Chemistry, Medicinal Chemistry, Organic

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A novel series of 2-thio-5-thiomethyl substituted imidazoles was discovered to be potent TGR5 agonists that possessed glucose-lowering effects while inhibiting gall bladder emptying in mice. (C) 2017 Elsevier Ltd. All rights reserved.

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