Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 13, Pages 11337-11344Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b15247
Keywords
multifunction nanoparticles; manganese dioxide; multidrug resistance; doxorubicin; theranostics
Funding
- National Natural Science Foundation of China [81573369, 51473109]
- Natural Science Foundation of Jiangsu Province [BK20140659]
- Project Program of State Key Laboratory of Natural Medicines, China Pharmaceutical University [SKLNMZZJQ201601]
- National High Technology Research and Development Program of China (863 Program) [2015AA020314]
- Outstanding Youth Fund of Jiangsu Province of China [BK20160031]
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Multidrug resistance (MDR) greatly impedes the therapeutic efficacy of chemotherapeutic agents. Overexpression of ATP-binding cassette (ABC) transporters, such as P-gp, on the surface of tumor cells is a major mechanism in MDR. In this study, we fabricated manganese dioxide (MnO2)/doxorubicin (DOX)-loaded albumin nanoparticles (BMDN) for magnetic resonance imaging and reversing MDR in resistant tumor. BMDN facilitated the delivery of DOX into MDR tumor cells through their MDR reversal effects including enhanced cellular uptake, reduced drug efflux, and decreased hypoxic tumor microenvironment. BMDN also acted as an effective MRI contrast agent, thereby causing good in vitro and in vivo T1-weighted imaging.
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