σ-Alkyl-PdII Species for Remote C-H Functionalization

The transition-metal-directed C-H activation processes have traditionally required the installation of suitable coordinating groups to place the metal in close proximity to an specific neighboring or remote C(sp(2))-H or C(sp(3))-H moiety of the molecular structure. Alternatively, substitution of C-H bonds at positions previously thought inaccessible are now performed through domino processes via insitu generated sigma-alkyl-Pd-II species. This Concept article highlights on recent developments which utilize these sigma-alky-Pd-II-species for remote C-H functionalization to reinvigorate new C-C bond formation in cascade fashion via use of catalytic palladium metal.