Journal
CANCER INVESTIGATION
Volume 35, Issue 3, Pages 174-186Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07357907.2016.1276187
Keywords
Chrysin; mitochondria; complex II; CLL; complex V
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Funding
- Shahid Beheshti University of Medical Sciences, Deputy of Research [1392-1132-1183]
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We investigated the effect of chrysin on isolated normal and chronic lymphocytic leukemia (CLL) B-lymphocytes and their isolated mitochondria. We report that a selective and significant increase in cytotoxicity, intracellular reactive oxygen species, mitochondrial membrane potential collapse, ADP/ATP ratio, caspase 3 activation and finally apoptosis in chrysin-treated CLL B- lymphocytes. Also we determined that chrysin selectively inhibits complex II and ATPases in cancerous mitochondria. In this study we proved that the ability of chrysin to promote apoptosis in CLL B-lymphocytes performed by selectively targeting of mitochondria. Our findings may provide a potential therapeutic approach for using chrysin to target mitochondria in CLL B-lymphocytes.
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