Journal
CELL HOST & MICROBE
Volume 21, Issue 5, Pages 561-567Publisher
CELL PRESS
DOI: 10.1016/j.chom.2017.04.007
Keywords
-
Categories
Funding
- NIH [R01 HD075665, R01 AI081759, R01 AI123348]
- Burroughs Wellcome Investigators in the Pathogenesis of Infectious Disease Award
Ask authors/readers for more resources
Congenital infections with pathogens such as Zika virus, Toxoplasma gondii, Listeria monocytogenes, Treponema pallidium, parvovirus, HIV, varicella zoster virus, Rubella, Cytomegalovirus, and Herpesviruses are a major cause of morbidity and mortality worldwide. Despite the devastating impact of microbial infections on the developing fetus, relatively little is known about how pathogens associated with congenital disease breach the placental barrier to transit vertically during human pregnancy. In this Review, we focus on transplacental transmission of pathogens during human gestation. We introduce the structure of the human placenta and describe the innate mechanisms by which the placenta restricts microbial access to the intrauterine compartment. Based on current knowledge, we also discuss the potential pathways employed by microorganisms to overcome the placental barrier and prospects for the future.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available