Journal
CHEMICAL REVIEWS
Volume 117, Issue 9, Pages 6538-6631Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.7b00097
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Funding
- National Science Foundation [DMR-1066116, DMR-1120901]
- P. Roy Vagelos Chair at the University of Pennsylvania
- Humboldt Foundation
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1066116] Funding Source: National Science Foundation
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Synthetic vesicles have been assembled and coassembled from phospholipids, their modified versions, and other single amphiphiles into liposomes, and from block copolymers into polymersomes. Their time-consuming synthesis and preparation as stable, monodisperse, and biocompatible liposomes and polymersomes called for the elaboration of new synthetic methodologies. Amphiphilic Janus dendrimers (JDs) and glycodendrimers (JGDs) represent the most recent self-assembling amphiphiles capable of forming monodisperse, stable, and multifunctional unilamellar and multilamellar onion-like vesicles denoted dendrimersomes (DSs) and glycodendrimersomes (GDSs), dendrimercubosomes (DCs), glycodendrimercubosomes (GDCs), and other complex architectures. Amphiphilic JDs consist of hydrophobic dendrons connected to hydrophilic dendrons and can be thought of as monodisperse oligomers of a single amphiphile. They can be functionalized with a variety of molecules such as dyes, and, in the case of JGDs, with carbohydrates. Their iterative modular synthesis provides efficient access to sequence control at the molecular level, resulting in topologies with specific epitope sequence and density. DSs, GDSs, and other architectures from JDs and JGDs serve as powerful tools for mimicking biological membranes and for biomedical applications such as targeted drug and gene delivery and theranostics. This Review covers all aspects of the synthesis of JDs and JGDs and their biological activity and applications after assembly in aqueous media.
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