Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 23, Issue 27, Pages 6464-6482Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201604617
Keywords
asymmetric catalysis; diastereodivergency; enantioselectivity
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Funding
- National Natural Science Foundation of China [21432006, 21572136]
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Chiral molecules with multiple stereocenters are widely distributed in nature and drugs. Asymmeric catalysis has allowed the formation of a chiral molecule's enantiomers with equal ease by applying the enantiomeric pair of a chiral catalyst. However, the diastereodivergent synthesis is a great challenge because the formation of one of the diastereomers is inherently preferred in most reactions. Under the efforts of chemists, elegant strategies have been developed to full control of absolute and relative stereochemical configurations. In this Minireview, we highlight the significant advances achieved in this field, and present the diastereo-control mechanism in the appropriate place on the expectation that new diastereodivergent strategies can be inspired and more types of enantioselective diastereodivergent reactions can be realized.
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