Journal
BIOLOGICAL PSYCHIATRY
Volume 81, Issue 10, Pages 838-847Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2016.05.011
Keywords
Autism spectrum disorders; Circuit; Excitation/inhibition balance; Mouse models; Psychiatric disorders; Synapse
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Funding
- Institute for Basic Science Grant [IBS-R002-D1]
- Ministry of Science & ICT (MSIT), Republic of Korea [IBS-R002-D1-2017-A00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Imbalances between excitation and inhibition in synaptic transmission and neural circuits have been implicated in autism spectrum disorders. Excitation and inhibition imbalances are frequently observed in animal models of autism spectrum disorders, and their correction normalizes key autistic-like phenotypes in these animals. These results suggest that excitation and inhibition imbalances may contribute to the development and maintenance of autism spectrum disorders and represent an important therapeutic target.
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