Journal
EUROPEAN JOURNAL OF NUTRITION
Volume 56, Issue 1, Pages 161-170Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00394-015-1066-z
Keywords
Body composition; Diabetes Prevention Program; Body weight; Obesity; Vitamin D; Adipose tissue
Categories
Funding
- National Institute of Diabetes and Digestive and Kidney Disease [R01DK79003]
- National Center for Research Resources [UL1RR025752]
- National Center for Advancing Translational Sciences, National Institutes of Health
- Gerald J. and Dorothy R. Friedman Foundation
- US Department of Agriculture [58-1950-9001]
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health [UO1DK48489]
- NIDDK, Intramural Research Program
- Indian Health Service
- National Institute of Child Health and Human Development
- National Institute on Aging
- National Eye Institute
- National Heart Lung and Blood Institute
- Office of Research on Women's Health
- National Center for Minority Health and Human Disease
- Centers for Disease Control and Prevention
- American Diabetes Association
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We examined associations between body weight and plasma 25-hydroxyvitamin D concentration (25OHD) in prediabetes and sought to estimate the impact of adiposity on these associations. The study was conducted in the placebo (n = 1082) and intensive lifestyle (n = 1079) groups of the Diabetes Prevention Program (DPP), a multicenter trial to prevent type 2 diabetes in adults with prediabetes. Weight and 25OHD were measured at baseline, month 6, years 1 and 2. In a subset (n = 584), visceral (VAT) and subcutaneous (SAT) adiposity were assessed by computed tomography at baseline and year 1. In cross-sectional analyses, baseline body weight, total fat, VAT, and SAT were inversely associated with plasma 25OHD concentration after multivariable adjustment. VAT accounted for 40 % [95 % CI 11, 69] of the association of body weight with plasma 25OHD concentration. There was no significant contribution by total fat or SAT. Two-year changes in plasma 25OHD concentration varied inversely with changes in body weight (p < 0.0001). One-year changes in total fat, VAT, or SAT were not significant mediators of the association between change in plasma 25OHD concentration and body weight. Our study found an inverse association between body weight and plasma 25OHD concentration at baseline and over a 2-year period in adults with prediabetes. These findings in the DPP, a weight loss intervention study, raise the possibility that weight loss increases plasma 25OHD concentration. Whether adiposity mediates this association remains inconclusive.
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