Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 114, Issue -, Pages 116-131Publisher
ELSEVIER
DOI: 10.1016/j.addr.2017.04.008
Keywords
Oral vaccines; Adjuvants; Oral delivery; Protein delivery; Mucosal immunization
Categories
Funding
- Cockrell Family Regents Chair
- National Science Foundation [DGE-1610403]
- Philanthropic Educational Organization
Ask authors/readers for more resources
While vaccination remains the most cost effective strategy for disease prevention, communicable diseases persist as the second leading cause of death worldwide. There is a need to design safe, novel vaccine delivery methods to protect against unaddressed and emerging diseases. Development of vaccines administered orally is preferable to traditional injection-based formulations for numerous reasons including improved safety and compliance, and easier manufacturing and administration. Additionally, the oral route enables stimulation of humoral and cellular immune responses at both systemic and mucosal sites to establish broader and long-lasting protection. However, oral delivery is challenging, requiring formulations to overcome the harsh gastrointestinal (GI) environment and avoid tolerance induction to achieve effective protection. Here we address the rationale for oral vaccines, including key biological and physicochemical considerations for next-generation oral vaccine design. (C) 2017 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available