Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 114, Issue -, Pages 43-59Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2017.07.005
Keywords
Immunotherapy; Nanotechnology; Cancer; Immune regulation; Lymphangiogenesis; Lymph node targeting
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Funding
- NIH [R21 A1130821, T32 HL07605, F32 HL134251]
- Fonds Pierre-Francois Vittone
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Lymphatic vessels are the primary route of communication from peripheral tissues to the immune system; as such, they represent an important component of local immunity. In addition to their transport functions, new immunomodulatory roles for lymphatic vessels and lymphatic endothelial cells have come to light in recent years, demonstrating that lymphatic vessels help shape immune responses in a variety of ways: promoting tolerance to self-antigens, archiving antigen for later presentation, dampening effector immune responses, and resolving inflammation, among others. In addition to these new biological insights, the growing field of immunoengineering has begun to explore therapeutic approaches to utilize or exploit the lymphatic system for immunotherapy. (C) 2017 Published by Elsevier B.V.
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