Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 32, Pages 4509-4512Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc09392b
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Funding
- MINECO [TEC2014-51940-C2-2-R, MAT2013-47869-C4-2-P, SEV-2015-0496]
- CONACYT
- EPSRC [EP/M005178/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/M005178/1] Funding Source: researchfish
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Gels formed by a gemini dicationic amphiphile incorporate a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affecting a number of gel properties but most importantly inducing remarkable fibre coiling at the microscopic level as a result of drug release from the gel. Drug release and skin permeation experiments show its potential for topical administration.
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