Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 15, Pages 12924-12929Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b02367
Keywords
diselenide; hyperbranched polymer; singlet oxygen; chemotherapy; stimuli response
Funding
- National Science Foundation for Distinguished Young Scholars [21425416]
- National Basic Research Program of China [2013CB834502]
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China [21421064]
- National Natural Science Foundation of China [91427301]
- Natural Science Foundation of Beijing for Young Scholars [2164064]
- China Postdoctoral Science Foundation [2016M590083]
Ask authors/readers for more resources
A light-induced cytotoxicity system was fabricated using active diselenide/porphyrin-containing hyperbranched polymer aggregates in aqueous solution through emulsification. When the nanoparticles were irradiated with visible light, O-I(2) was produced by the porphyrin photosensitizers in the system, which cleaved the diselenide bonds in the polymer chains and disassembled the nanosystem. Interestingly, the oxidized products exhibited cytotoxicity to the MDA-MB 231cell line without using extra anticancer drugs, which endowed the system with potential visible light-induced antitumor activity. In combination with photodynamic therapy, it is greatly anticipated that better anticancer efficacy can be achieved with this system.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available