Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 29, Pages 4152-4155Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc00247e
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Funding
- Ministry of Science and Technology and Academia Sinica, Taiwan [105-0210-01-13-01, MOST-104-2113-M-001-015-MY3, MOST 105-2113-M-037-MY2, AS-105-TP-A04]
- Taiwan Ministry of Health and Welfare [CMRPG3C1141]
- Chang Gung Memorial Hospital [102-3107B]
- Academia Sinica [AS-IRB01-14031]
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We design and synthesize EpCAM antibodies with Fc-domain site-specific linkers that allow preferential alignment when coated on microfluidic devices for capturing circulating tumor cells (CTCs) from colorectal cancer patients. The aligned coating is shown to increase the capture efficiency of CTCs and microemboli by 1.6 and 3.0-fold, respectively (both P < 0.05).
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