Journal
ANNALS OF NEUROLOGY
Volume 81, Issue 4, Pages 604-608Publisher
WILEY
DOI: 10.1002/ana.24914
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Funding
- Ministry of Education, Science, Sports, and Culture of Japan [16K19516]
- Grants-in-Aid for Scientific Research [15K08597, 16K19516, 15K19184, 15K09318, 15H04841] Funding Source: KAKEN
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We aimed to assess the possibility of using a noninvasive screening method for hereditary transthyretin amyloidosis by means of abdominal fat ultrasonography. Quantitative analysis of ultrasound B-mode images demonstrated a significant increase in mean echogenicity and a loss of the normal structure of the layers of fat tissue in patients with hereditary transthyretin amyloidosis (n = 19). The ultrasound features of the fat tissue and the degree of amyloid deposition seen histopathologically showed a significant correlation. These results suggest that abdominal fat ultrasonography may be a valuable method for screening for hereditary transthyretin amyloidosis.
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