Journal
CURRENT ALLERGY AND ASTHMA REPORTS
Volume 17, Issue 4, Pages -Publisher
CURRENT MEDICINE GROUP
DOI: 10.1007/s11882-017-0694-1
Keywords
Cockroach allergy; Asthma; IgE; Allergy diagnosis; Recombinant allergens; Allergen structure
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Funding
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [R01AI077653]
- Sao Paulo State Research Funding Agency (FAPESP)
- Brazilian National Research Council - National Institutes of Science and Technology, Institute of Investigation in Immunology (CNPq-INCT-iii)
- Intramural Research Program of the National Institute of Environmental Health Sciences [Z01-ES102906-01]
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Purpose of Review This review addresses the most recent developments on cockroach allergen research in relation to allergic diseases, especially asthma. Recent Findings The number of allergens relevant to cockroach allergy has recently expanded considerably up to 12 groups. New X-ray crystal structures of allergens from groups 1, 2, and 5 revealed interesting features with implications for allergen standardization, sensitization, diagnosis, and therapy. Summary Cockroach allergy is strongly associated with asthma particularly among children and young adults living in inner-city environments, posing challenges for disease control. Environmental interventions targeted at reducing cockroach allergen exposure have provided conflicting results. Immunotherapy may be a way to modify the natural history of cockroach allergy and decrease symptoms and asthma severity among sensitized and exposed individuals. The new information on cockroach allergens is important for the assessment of allergen markers of exposure and disease, and for the design of immunotherapy trials.
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