Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 359, Issue 10, Pages 1742-1746Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201601345
Keywords
Asymmetric synthesis; cyclopropanation; ruthenium catalyst; diazo Weinreb amide
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Funding
- Japan Society for the Promotion of Science [26288087]
- Grants-in-Aid for Scientific Research [26288087] Funding Source: KAKEN
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Inter- and intramolecular cyclopropanations of a series of diazo Weinreb amides and trans-allylic diazo Weinreb amide derivatives have been achieved using chiral ruthenium(II)-Amm-Pheox catalyst to give the corresponding chiral cyclopropyl Weinreb amides in excellent yield (up to 99%) with excellent enantioselectivity (up to 99% ee). The chiral products could easily undergo useful synthetic transformations to give the corresponding aldehydes, alcohols and ketones in high yields and enantioselectivities.
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