Journal
ADVANCED MATERIALS
Volume 29, Issue 19, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201606690
Keywords
vesicles; photosensitizers; photodynamic therapy; photothermal therapy; tumor ablation
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Funding
- National Basic Research Program [2014CB931900]
- National Natural Science Foundation of China [31422021, 81402779, 21401136, 51473109, 21274096]
- Natural Science Foundation of Jiangsu Province of China [BK20140369]
- Natural Science Foundation for Colleges and Universities in Jiangsu Province of China [14KJB350004]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection
- Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases
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Photoconversion tunability of fluorophore dye is of great interest in cancer nanomedicine such as fluorescence imaging, photodynamic therapy (PDT), and photothermal therapy (PTT). Herein, this paper reports wavelength-dependent photoconversional polymeric vesicles of boron dipyrromethene (Bodipy) fluorophore for either PDT under 660 nm irradiation or PTT under 785 nm irradiation. After being assembled within polymeric vesicles at a high drug loading, Bodipy molecules aggregate in the conformations of both J-type and H-type, thereby causing red-shifted absorption into near-infrared region, ultralow radiative transition, and ideal resistance to photobleaching. Such vesicles further possess enhanced blood circulation, preferable tumor accumulation, as well as superior cell uptake as compared to free Bodipy. In particular, the vesicles mainly generate abundant intracellular singlet oxygen for PDT treatment under 660 nm irradiation, while they primarily produce a potent hyperthermia for PTT with tumor ablation through singlet oxygen-synergized photothermal necrosis under 785 nm irradiation. This approach provides a facile and general strategy to tune photoconversion characteristics of fluorophore dyes for wavelength-dependent photoinduced cancer therapy.
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