Journal
AMERICAN JOURNAL OF DERMATOPATHOLOGY
Volume 39, Issue 5, Pages 325-341Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/DAD.0000000000000638
Keywords
collagenoma; connective tissue nevi; elastoma; elastosis perforans serpiginosa; focal mucinosis; hunter's syndrome; lichen myxedematosus; pseudoxanthoma elasticum
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Connective tissue nevi (CTN) are hamartomas of the dermis, with the 3 main components being collagen, elastin, and proteoglycans. Each subtype can present as a solitary lesion or multiple lesions. They could present as part of systemic diseases or inherited disorders. This article provides a comprehensive literature review of the different types of CTN, their clinical presentations, associations, and treatment options. Treatment options for 56 lesions were reviewed. Fifty-two percent of lesions were present in males, and the age range at the time of presentation was wide (1.6-80 years). Management varied according to CTN subtypes. Most lesions (14) received topical or intralesional treatment with corticosteroids, followed by surgical removal of lesions (12), whereas the remaining lesions were clinically monitored.
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