A chiral, porous, organic cage-based, enantioselective potentiometric sensor for 2-aminobutanol

A new enantioselective potentiometric sensor containing R-type chiral porous organic cage CC9 as the chiral selector was designed for the assay of 2-aminobutanol. Optimized membrane electrodes displayed a linear dynamic range from 10(-3) similar to 10(-1) mol.L-1 with a detection limit of 2.5 x 10(-4) mol.L-1 and a Nernstian response of 27 +/- 0.5 mV.decade(-1) toward S-2-aminobutanol within the pH range 7.0-10.0. The potentiometric enantioselectivity coefficient (logK(S,R)(Pot)) of this sensor was -1.333, indicating that the porous organic cage-based electrode exhibited good discrimination toward S-2-aminobutanol over R-2-aminobutanol.