Journal
CURRENT BIOLOGY
Volume 27, Issue 10, Pages 1437-+Publisher
CELL PRESS
DOI: 10.1016/j.cub.2017.04.014
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [23113520, 25113724]
- Human Frontier Science Program [HFSP RGP0015/2010]
- Uehara Memorial Foundation
- Naito Foundation
- KAO Corporation
- JST ERATO Touhara Chemosensory Signal Project [JPMJER1202]
- [20300117]
- [25430025]
- [16K07018]
- [25115005]
- Grants-in-Aid for Scientific Research [15H06860, 25113724] Funding Source: KAKEN
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Nucleotides released from food sources into environmental water are supposed to act as feeding cues for many fish species. However, it remains unknown how fish can sensitively detect those nucleotides. Here we discover a novel olfactory mechanism for ATP sensing in zebrafish. Upon entering into the nostril, ATP is efficiently converted into adenosine through enzymatic reactions of two ecto-nucleotidases expressed in the olfactory epithelium. Adenosine subsequently activates a small population of olfactory sensory neurons expressing a novel adenosine receptor A2c that is unique to fishes and amphibians. The information is then transmitted to a single glomerulus in the olfactory bulb and further to four regions in higher olfactory centers. These results provide conclusive evidence for a sophisticated enzyme-linked receptor mechanism underlying detection of ATP as a food-derived attractive odorant linking to foraging behavior that is crucial and common to aquatic lower vertebrates.
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