Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 22, Pages 6198-6202Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201701605
Keywords
gold nanoparticles; N-heterocyclic carbenes; photoacoustic effect; stability; water solubility
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Funding
- JSPS [26288023]
- NU [26288023]
- Natural Sciences and Engineering Research Council of Canada
- Grants-in-Aid for Scientific Research [16K13962, 26288023, 16K13097] Funding Source: KAKEN
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NHC-Au-I complexes were used to prepare stable, water-soluble, NHC-protected gold nanoparticles. The water-soluble, charged nature of the nanoparticles permitted analysis by polyacrylamide gel electrophoresis (PAGE), which showed that the nanoparticles were highly monodisperse, with tunable core diameters between 2.0 and 3.3 nm depending on the synthesis conditions. Temporal, thermal, and chemical stability of the nanoparticles were determined to be high. Treatment with thiols caused etching of the particles after 24 h; however larger plasmonic particles showed greater resistance to thiol treatment. These water-soluble, bio-compatible nanoparticles are promising candidates for use in photoacoustic imaging, with even the smallest nanoparticles giving reliable photoacoustic signals.
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