Journal
BIOCHIMIE
Volume 136, Issue -, Pages 90-99Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2016.10.019
Keywords
Breast cancer; Lung cancer; Ovarian cancer; Peroxisome proliferator-activated receptor beta/delta; Transcriptional regulation
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [Mu601/17-1]
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The nuclear receptor factor peroxisome proliferator-activated receptor (PPAR beta/delta) can regulate its target genes by transcriptional activation or repression through both ligand-dependent and independent mechanism as well as by interactions with other transcription factors. PPAR beta/delta exerts essential regulatory functions in intermediary metabolism that have been elucidated in detail, but clearly also plays a role in inflammation, differentiation, apoptosis and other cancer-associated processes, which is, however, mechanistically only partly understood. Consistent with these functions clinical associations link the expression of PPAR beta/delta and its target genes to an unfavorable outcome of several human cancers. However, the available data do not yield a clear picture of PPAR beta/delta role in cancer-associated processes and are in fact partly controversial. This article provides an overview of this research area and discusses the role of PPAR beta/delta in cancer in light of the complex mechanisms of its transcriptional regulation and its potential as a druggable anti-cancer target. (C) 2016 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
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