Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 16, Pages 13988-13998Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b04808
Keywords
shape memory blend; biomedical stent; biodegradation; blood compatibility; drug release
Funding
- National Natural Science Foundation of China [51227802, 51421061]
- Open Research Fund of Key Laboratory of Special Materials and Preparation Technologies (Xihua University)
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Biocompatible poly(propylene carbonate) (PPC)/polycaprolactone (PCL) shape memory blends were fabricated using melt blending. The shape memory performance of these blends was found to depend remarkably on their components. On addition of 25 vol % PCL, one blend (PL-25) achieved an optimal shape-fixing ratio (R-f) and -recovery ratio (R-r).Specifically, its R-r considerably increased by 24.1 and 50.0% compared with those of pure PPC and PCL, respectively, because of the restricted irreversible deformation of the amorphous chains cross-linked by tiny crystals. After undergoing three thermomechanical cycles, R-f and R-r reached 97.0%. The PL-25 blend was further melt-processed into a stent, which showed a fast response and self-expansion at 37 C-circle. These results, along with those obtained from evaluating the material's blood compatibility, in vitro degradation and drug release behavior, demonstrated the great potential of PL-25 for biomedical applications.
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